Cu-Catalyzed aerobic oxidative cleavage of C(sp3)–C(sp3) bond: Synthesis of α-ketoamides

Jingming Zhang, Chengkou Liu, Man Yang, Zheng Fang, Kai Guo

科研成果: 期刊稿件文章同行评审

8 引用 (Scopus)

摘要

A novel synthesis of α-ketoamides from Cu-catalyzed aerobic oxidative C(sp3)–C(sp3) bond cleavage of hydrocinnamaldehydes has been developed. Readily available and environmentally benign oxygen is used as the oxidant. This reaction avoids the use of noble metal catalysts or specialized oxidants, and chemoselectively yields α-ketoamide. Moreover, based on various control experiments, a reasonable mechanism is proposed.

源语言英语
文章编号152555
期刊Tetrahedron Letters
61
47
DOI
出版状态已出版 - 19 11月 2020

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