Current advance in biological production of malic acid using wild type and metabolic engineered strains

Zhongxue Dai, Huiyuan Zhou, Shangjie Zhang, Honglian Gu, Qiao Yang, Wenming Zhang, Weiliang Dong, Jiangfeng Ma, Yan Fang, Min Jiang, Fengxue Xin

科研成果: 期刊稿件文献综述同行评审

89 引用 (Scopus)

摘要

Malic acid (2-hydroxybutanedioic acid) is a four-carbon dicarboxylic acid, which has attracted great interest due to its wide usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Several mature routes for malic acid production have been developed, such as chemical synthesis, enzymatic conversion and biological fermentation. With depletion of fossil fuels and concerns regarding environmental issues, biological production of malic acid has attracted more attention, which mainly consists of three pathways, namely non-oxidative pathway, oxidative pathway and glyoxylate cycle. In recent decades, metabolic engineering of model strains, and process optimization for malic acid production have been rapidly developed. Hence, this review comprehensively introduces an overview of malic acid producers and highlight some of the successful metabolic engineering approaches.

源语言英语
页(从-至)345-353
页数9
期刊Bioresource Technology
258
DOI
出版状态已出版 - 6月 2018

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