GC-MS analysis of impurities in p-phenetidine sample

A GC-MS method was established to analyze the impurities of p-phenetidine sample. The structure of the impurities were identified to be N-methyl-4-ethoxybenzenamine, N-ethyl-4-ethoxy-benzenamine, N-methoxy-4-ethoxybenzenamine, N-(4-ethoxybenzenamine) phenyl-1, 4-diamine and N ¹-ethoxy-N ⁴-Cethoxybenzenamine) phenyl-1,4-diamine by MS, and indicated that the impurities mainly resulted from the reaction conditions and the solvent methanol. This GC-MS method is very useful for the later research.