Green synthesis of reduced graphene oxide by a GRAS strain Bacillus subtilis 168 with high biocompatibility to zebrafish embryos

Tingting Liu, Ling Ling Jiang, Ming Fang He, Zhengang Zhu, De Bin Wang, Tian Shun Song, Wei Min Tan, Pingkai Ouyang, Jingjing Xie

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16 引用 (Scopus)

摘要

Low toxic and highly biocompatible graphene-based nanomaterials are in high demand within the biomedical fields. In this study, a highly biocompatible bacterially reduced graphene oxide (BRGO) was prepared by a "Generally Recognized As Safe" (GRAS) strain Bacillus subtilis 168 mediated with Vitamin K3 (VK3). The hypothesis of VK3 mediating electron transfer between succinate:quinine oxidoreductase, from B. subtilis 168, and graphene oxide (GO) was proposed. BRGO was characterized by Raman spectroscopy, XPS and XRD and showed excellent properties. Furthermore, BRGO illustrates greater biocompatibility, with less toxicity, than GO and chemically reduced graphene oxide (CRGO) by zebrafish toxicity assessment, which demonstrates its great potential in various biomedical applications.

源语言英语
页(从-至)60024-60032
页数9
期刊RSC Advances
5
74
DOI
出版状态已出版 - 2015

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