Indium - Copper-mediated barbier - Grignard-type alkylation reaction of imines in aqueous media

Zhi Liang Shen; Teck Peng Loh

doi:10.1021/ol702263b

Indium - Copper-mediated barbier - Grignard-type alkylation reaction of imines in aqueous media

Zhi Liang Shen, Teck Peng Loh

Nanyang Technological University

科研成果: 期刊稿件 › 文章 › 同行评审

52 引用（Scopus）

摘要

An efficient system of In/Cul/InCl₃ was developed for Barbier-Grignard-type alkylation reactions of simple imines, using a one-pot condensation of various aldehydes, amines (including aliphatic and chiral version), and alkyl iodides in water or aqueous media. The reactions proceeded efficiently at room temperature to give the desired products in moderate to good yields. Good diastereoselectivities were obtained when using L-valine methyl ester as substrate.

源语言	英语
页（从-至）	5413-5416
页数	4
期刊	Organic Letters
卷	9
期	26
DOI	https://doi.org/10.1021/ol702263b
出版状态	已出版 - 20 12月 2007
已对外发布	是

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abstract = "An efficient system of In/Cul/InCl3 was developed for Barbier-Grignard-type alkylation reactions of simple imines, using a one-pot condensation of various aldehydes, amines (including aliphatic and chiral version), and alkyl iodides in water or aqueous media. The reactions proceeded efficiently at room temperature to give the desired products in moderate to good yields. Good diastereoselectivities were obtained when using L-valine methyl ester as substrate.",

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AB - An efficient system of In/Cul/InCl3 was developed for Barbier-Grignard-type alkylation reactions of simple imines, using a one-pot condensation of various aldehydes, amines (including aliphatic and chiral version), and alkyl iodides in water or aqueous media. The reactions proceeded efficiently at room temperature to give the desired products in moderate to good yields. Good diastereoselectivities were obtained when using L-valine methyl ester as substrate.

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Indium - Copper-mediated barbier - Grignard-type alkylation reaction of imines in aqueous media

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