Indium-mediated difunctionalization of iodoalkyl-tethered unactivated alkenes: Via an intramolecular cyclization and an ensuing palladium-catalyzed cross-coupling reaction with aryl halides

Xuan Di Song, Xiang Rui Li, Ya Wen Wang, Xue Qiang Chu, Weidong Rao, Haiyan Xu, Guo Zhi Han, Zhi Liang Shen

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20 引用 (Scopus)

摘要

An efficient cobalt-catalyzed, indium-mediated difunctionalization of iodoalkyl-tethered unactivated alkenes via a cyclization/cross-coupling sequence was developed. The reactions proceeded effectively with wide functional group tolerance, leading to a wide variety of cyclic compounds, including cyclopentane, furan, pyrrolidine, octahydro-1H-indene, octahydro-benzofuran, hexahydro-4H-furo[2,3-b]pyran, and hexahydro-furo[2,3-b]furan, which are pivotal cores widely found in pharmaceutical and bioactive compounds.

源语言英语
页(从-至)2703-2709
页数7
期刊Organic Chemistry Frontiers
7
18
DOI
出版状态已出版 - 21 9月 2020

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