Indium/copper-mediated conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds in water

Zhi Liang Shen; Hao Lun Cheong; Teck Peng Loh

doi:10.1016/j.tetlet.2008.12.079

Indium/copper-mediated conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds in water

Zhi Liang Shen, Hao Lun Cheong, Teck Peng Loh

Nanyang Technological University

科研成果: 期刊稿件 › 文章 › 同行评审

31 引用（Scopus）

摘要

An efficient method for the conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds using indium/copper in water is described. The reactions proceed more efficiently in water than in organic solvents. In, CuI, and InCl₃ are all essential for efficient reaction. Formation of a symmetrical vic-diarylalkane is observed when an aryl-substituted alkene is used as substrate.

源语言	英语
页（从-至）	1051-1054
页数	4
期刊	Tetrahedron Letters
卷	50
期	9
DOI	https://doi.org/10.1016/j.tetlet.2008.12.079
出版状态	已出版 - 4 3月 2009
已对外发布	是

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abstract = "An efficient method for the conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds using indium/copper in water is described. The reactions proceed more efficiently in water than in organic solvents. In, CuI, and InCl3 are all essential for efficient reaction. Formation of a symmetrical vic-diarylalkane is observed when an aryl-substituted alkene is used as substrate.",

keywords = "Alkyl iodide, Conjugate addition, Copper, Indium, Water, α,β-Unsaturated carbonyl compounds",

author = "Shen, {Zhi Liang} and Cheong, {Hao Lun} and Loh, {Teck Peng}",

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AU - Shen, Zhi Liang

AU - Cheong, Hao Lun

AU - Loh, Teck Peng

PY - 2009/3/4

Y1 - 2009/3/4

N2 - An efficient method for the conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds using indium/copper in water is described. The reactions proceed more efficiently in water than in organic solvents. In, CuI, and InCl3 are all essential for efficient reaction. Formation of a symmetrical vic-diarylalkane is observed when an aryl-substituted alkene is used as substrate.

AB - An efficient method for the conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds using indium/copper in water is described. The reactions proceed more efficiently in water than in organic solvents. In, CuI, and InCl3 are all essential for efficient reaction. Formation of a symmetrical vic-diarylalkane is observed when an aryl-substituted alkene is used as substrate.

KW - Alkyl iodide

KW - Conjugate addition

KW - Copper

KW - Indium

KW - Water

KW - α,β-Unsaturated carbonyl compounds

UR - http://www.scopus.com/inward/record.url?scp=58149492480&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2008.12.079

DO - 10.1016/j.tetlet.2008.12.079

M3 - 文章

AN - SCOPUS:58149492480

SN - 0040-4039

VL - 50

SP - 1051

EP - 1054

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 9

ER -

Indium/copper-mediated conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds in water

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