Multifaceted Roles of Copper Ions in Anticancer Nanomedicine

Siyuan Yang, Yingnan Song, Yanling Hu, Hong Jin Chen, Dongliang Yang, Xuejiao Song

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37 引用 (Scopus)

摘要

The significantly increased copper level in tumor tissues and serum indicates the close association of copper ions with tumor development, making copper ions attractive targets in the development of novel tumor treatment methods. The advanced nanotechnology developed in the past decades provides great potential for tumor therapy, among which Cu-based nanotherapeutic systems have received greater attention. Herein, the multifaceted roles of copper ions in cancer progression are summarized and the recent advances in the copper-based nanostructures or nanomedicines for different kinds of tumor therapies including copper depletion therapy, copper-based cytotoxins, copper-ion-based chemodynamic therapy and its combination with other treatments, and copper-ion-induced ferroptosis and cuproptosis activation are discussed. Furthermore, the perspectives for the further development of copper-ion-based nanomedicines for tumor therapy and clinic translation are presented by the authors.

源语言英语
文章编号2300410
期刊Advanced Healthcare Materials
12
23
DOI
出版状态已出版 - 13 9月 2023

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