摘要
The NH4I-triggered formal [4 + 2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides has been developed. The current protocol employs electron-rich enamides as C2 synthons and enables the efficient and straightforward construction of polysubstituted pyridines in moderate to good yields based on metal-free systems. The reaction tolerates a wide range of functional groups and represents an alternate route toward the synthesis of pyridine derivatives.
源语言 | 英语 |
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页(从-至) | 8157-8165 |
页数 | 9 |
期刊 | Journal of Organic Chemistry |
卷 | 85 |
期 | 12 |
DOI | |
出版状态 | 已出版 - 19 6月 2020 |