NH4I-Triggered [4 + 2] Annulation of α,β-Unsaturated Ketoxime Acetates with N-Acetyl Enamides for the Synthesis of Pyridines

Jindian Duan, Lei Zhang, Gaochen Xu, Heming Chen, Xiaojuan Ding, Yiyang Mao, Binsen Rong, Ning Zhu, Kai Guo

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38 引用 (Scopus)

摘要

The NH4I-triggered formal [4 + 2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides has been developed. The current protocol employs electron-rich enamides as C2 synthons and enables the efficient and straightforward construction of polysubstituted pyridines in moderate to good yields based on metal-free systems. The reaction tolerates a wide range of functional groups and represents an alternate route toward the synthesis of pyridine derivatives.

源语言英语
页(从-至)8157-8165
页数9
期刊Journal of Organic Chemistry
85
12
DOI
出版状态已出版 - 19 6月 2020

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