Palladium-catalyzed direct C-H arylation of enamides with simple arenes

Sreekumar Pankajakshan; Yun He Xu; Jun Kee Cheng; Man Ting Low; Teck Peng Loh

doi:10.1002/anie.201109247

Palladium-catalyzed direct C-H arylation of enamides with simple arenes

Sreekumar Pankajakshan, Yun He Xu, Jun Kee Cheng, Man Ting Low, Teck Peng Loh

科研成果: 期刊稿件 › 文章 › 同行评审

149 引用（Scopus）

摘要

Z only: An atom-economical synthetic route towards arylated Z-enamides through double C-H functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B).

源语言	英语
页（从-至）	5701-5705
页数	5
期刊	Angewandte Chemie - International Edition
卷	51
期	23
DOI	https://doi.org/10.1002/anie.201109247
出版状态	已出版 - 4 6月 2012
已对外发布	是

访问文件

10.1002/anie.201109247

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{d16a478fe8334e0584d2b49649a8b5f8,

title = "Palladium-catalyzed direct C-H arylation of enamides with simple arenes",

abstract = "Z only: An atom-economical synthetic route towards arylated Z-enamides through double C-H functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B).",

keywords = "C-H functionalization, arylation, enamides, palladium, synthetic methods",

author = "Sreekumar Pankajakshan and Xu, {Yun He} and Cheng, {Jun Kee} and Low, {Man Ting} and Loh, {Teck Peng}",

year = "2012",

month = jun,

day = "4",

doi = "10.1002/anie.201109247",

language = "英语",

volume = "51",

pages = "5701--5705",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "23",

}

TY - JOUR

T1 - Palladium-catalyzed direct C-H arylation of enamides with simple arenes

AU - Pankajakshan, Sreekumar

AU - Xu, Yun He

AU - Cheng, Jun Kee

AU - Low, Man Ting

AU - Loh, Teck Peng

PY - 2012/6/4

Y1 - 2012/6/4

N2 - Z only: An atom-economical synthetic route towards arylated Z-enamides through double C-H functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B).

AB - Z only: An atom-economical synthetic route towards arylated Z-enamides through double C-H functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B).

KW - C-H functionalization

KW - arylation

KW - enamides

KW - palladium

KW - synthetic methods

UR - http://www.scopus.com/inward/record.url?scp=84861625900&partnerID=8YFLogxK

U2 - 10.1002/anie.201109247

DO - 10.1002/anie.201109247

M3 - 文章

AN - SCOPUS:84861625900

SN - 1433-7851

VL - 51

SP - 5701

EP - 5705

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 23

ER -

Palladium-catalyzed direct C-H arylation of enamides with simple arenes

摘要

访问文件

其它文件与链接

指纹

引用此