Preparation and safety of brevescapine inclusion complex freeze-dried powder injection

Hui Ying Zhang; Xue Ming Li; Guo Guang Chen; Ping Wei

Preparation and safety of brevescapine inclusion complex freeze-dried powder injection

Hui Ying Zhang, Xue Ming Li, Guo Guang Chen, Ping Wei

生物与制药工程学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

OBJECTIVE: To prepare brevescapine (BRE) inclusion complex freeze-dried powder injection and evaluate its safety. METHODS: BRE-HP-β3-CD inclusion complex was prepared by freeze-dried method using HP-β-CD as inclusion material. The molar ratio between host and guest was optimized by continuing variational method. The inclusion compound was identified by Infrared Spectra (IR) and Differential Scanning Calorimetry (DSC) methods. HPLC was used to determine the solubility of BRE in the inclusion complex. RESULTS: The formulation was prepared and the conclusion molar ratio was 1:2. The solubility was evidently increased and it had no hemolytic and irritant effect. CONCLUSION: Brevescapine inclusion complex freeze-dried powder injection can be prepared by addition of HP-β-CD. The safety is eligible.

源语言	英语
页（从-至）	457-460
页数	4
期刊	Chinese Pharmaceutical Journal
卷	42
期	6
出版状态	已出版 - 3月 2007

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abstract = "OBJECTIVE: To prepare brevescapine (BRE) inclusion complex freeze-dried powder injection and evaluate its safety. METHODS: BRE-HP-β3-CD inclusion complex was prepared by freeze-dried method using HP-β-CD as inclusion material. The molar ratio between host and guest was optimized by continuing variational method. The inclusion compound was identified by Infrared Spectra (IR) and Differential Scanning Calorimetry (DSC) methods. HPLC was used to determine the solubility of BRE in the inclusion complex. RESULTS: The formulation was prepared and the conclusion molar ratio was 1:2. The solubility was evidently increased and it had no hemolytic and irritant effect. CONCLUSION: Brevescapine inclusion complex freeze-dried powder injection can be prepared by addition of HP-β-CD. The safety is eligible.",

keywords = "2-hydropropyl-β-cyclodextrin, Brevescapine, Freeze-dried, Inclusion complex, Safety",

author = "Zhang, {Hui Ying} and Li, {Xue Ming} and Chen, {Guo Guang} and Ping Wei",

year = "2007",

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T1 - Preparation and safety of brevescapine inclusion complex freeze-dried powder injection

AU - Zhang, Hui Ying

AU - Li, Xue Ming

AU - Chen, Guo Guang

AU - Wei, Ping

PY - 2007/3

Y1 - 2007/3

N2 - OBJECTIVE: To prepare brevescapine (BRE) inclusion complex freeze-dried powder injection and evaluate its safety. METHODS: BRE-HP-β3-CD inclusion complex was prepared by freeze-dried method using HP-β-CD as inclusion material. The molar ratio between host and guest was optimized by continuing variational method. The inclusion compound was identified by Infrared Spectra (IR) and Differential Scanning Calorimetry (DSC) methods. HPLC was used to determine the solubility of BRE in the inclusion complex. RESULTS: The formulation was prepared and the conclusion molar ratio was 1:2. The solubility was evidently increased and it had no hemolytic and irritant effect. CONCLUSION: Brevescapine inclusion complex freeze-dried powder injection can be prepared by addition of HP-β-CD. The safety is eligible.

AB - OBJECTIVE: To prepare brevescapine (BRE) inclusion complex freeze-dried powder injection and evaluate its safety. METHODS: BRE-HP-β3-CD inclusion complex was prepared by freeze-dried method using HP-β-CD as inclusion material. The molar ratio between host and guest was optimized by continuing variational method. The inclusion compound was identified by Infrared Spectra (IR) and Differential Scanning Calorimetry (DSC) methods. HPLC was used to determine the solubility of BRE in the inclusion complex. RESULTS: The formulation was prepared and the conclusion molar ratio was 1:2. The solubility was evidently increased and it had no hemolytic and irritant effect. CONCLUSION: Brevescapine inclusion complex freeze-dried powder injection can be prepared by addition of HP-β-CD. The safety is eligible.

KW - 2-hydropropyl-β-cyclodextrin

KW - Brevescapine

KW - Freeze-dried

KW - Inclusion complex

KW - Safety

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M3 - 文章

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SN - 1001-2494

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SP - 457

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JO - Chinese Pharmaceutical Journal

JF - Chinese Pharmaceutical Journal

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Preparation and safety of brevescapine inclusion complex freeze-dried powder injection

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