Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Xinyi Lv, Leichen Wang, Anqing Mei, Yan Xu, Xiaohong Ruan, Wenjun Wang, Jinjun Shao, Dongliang Yang, Xiaochen Dong

科研成果: 期刊稿件文献综述同行评审

107 引用 (Scopus)

摘要

Bacterial biofilm-related infectious diseases severely influence human health. Under typical situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are functional aggregates that coat bacteria with extracellular polymeric substances (EPS). The main reason for the failure of biofilm infection treatment is the low permeability and enrichment of therapeutic agents within the biofilm, which results from the particular features of biofilm matrix barriers such as negatively charged biofilm components and highly viscous compact EPS structures. Hence, developing novel therapeutic strategies with enhanced biofilm penetrability is crucial. Herein, the current progress of nanotechnology methods to improve therapeutic agents’ penetrability against biofilm matrix, such as regulating material morphology and surface properties, utilizing the physical penetration of nano/micromotors or microneedle patches, and equipping nanoparticles with EPS degradation enzymes or signal molecules, is first summarized. Finally, the challenges, perspectives, and future implementations of engineered delivery systems to manage biofilm infections are presented in detail.

源语言英语
文章编号2206220
期刊Small
19
6
DOI
出版状态已出版 - 8 2月 2023

指纹

探究 'Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers' 的科研主题。它们共同构成独一无二的指纹。

引用此