Selective single C-F bond arylation of trifluoromethylalkene derivatives

Luning Tang; Ze Yao Liu; Wenzhi She; Chao Feng

doi:10.1039/c9sc01966a

Selective single C-F bond arylation of trifluoromethylalkene derivatives

Luning Tang, Ze Yao Liu, Wenzhi She, Chao Feng

化学与分子工程学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

68 引用（Scopus）

摘要

A strategically novel single C-F bond functionalization of CF₃-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of S_N2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF₃-alkene and arylboronic acid derivatives.

源语言	英语
页（从-至）	8701-8705
页数	5
期刊	Chemical Science
卷	10
期	37
DOI	https://doi.org/10.1039/c9sc01966a
出版状态	已出版 - 2019

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abstract = "A strategically novel single C-F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of SN2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.",

author = "Luning Tang and Liu, {Ze Yao} and Wenzhi She and Chao Feng",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2019.",

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doi = "10.1039/c9sc01966a",

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T1 - Selective single C-F bond arylation of trifluoromethylalkene derivatives

AU - Tang, Luning

AU - Liu, Ze Yao

AU - She, Wenzhi

AU - Feng, Chao

PY - 2019

Y1 - 2019

N2 - A strategically novel single C-F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of SN2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.

AB - A strategically novel single C-F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of SN2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.

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U2 - 10.1039/c9sc01966a

DO - 10.1039/c9sc01966a

M3 - 文章

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SN - 2041-6520

VL - 10

SP - 8701

EP - 8705

JO - Chemical Science

JF - Chemical Science

IS - 37

ER -

Selective single C-F bond arylation of trifluoromethylalkene derivatives

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