Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies

Jianguo Sun; Guangji Wang; Wei Wang; Shuai Zhao; Yi Gu; Jinwen Zhang; Mingwen Huang; Fen Shao; Hao Li; Qi Zhang; Haitang Xie

doi:10.1016/j.jpba.2005.03.041

Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies

Jianguo Sun, Guangji Wang, Wei Wang, Shuai Zhao, Yi Gu, Jinwen Zhang, Mingwen Huang, Fen Shao, Hao Li, Qi Zhang, Haitang Xie

China Pharmaceutical University

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31 引用（Scopus）

摘要

To support the pharmacokinetic and bioavailability study of an extended-release loratadine (LOR)/pseudoephedrine sulfate (PES) tablet, a high performance liquid chromatographic-electrospray ionisation-mass spectrometric method (LC-MS) was developed for the simultaneous determination of LOR and PES in human plasma. Diazepam (DP) and phenylpropanolamine (PPA) were used as internal standards for LOR and PES, respectively. Analytes were extracted from alkalized human plasma by liquid/liquid extraction using ethyl ether. Chromatographic separation was performed on an ODS column at flow rate of 0.2 ml/min. The total chromatographic run time was 10.5 min with the retention time of 7.1 min and 6.2 min for LOR and DP, respectively, and 2.2 min for both of PES and PPA. The LOQ was 10 pg/ml and 50 pg/ml for LOR and PES, respectively. The method is accurate and precise enough for its intended purpose.

源语言	英语
页（从-至）	217-224
页数	8
期刊	Journal of Pharmaceutical and Biomedical Analysis
卷	39
期	1-2
DOI	https://doi.org/10.1016/j.jpba.2005.03.041
出版状态	已出版 - 1 9月 2005
已对外发布	是

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Sun, J., Wang, G., Wang, W., Zhao, S., Gu, Y., Zhang, J., Huang, M., Shao, F., Li, H., Zhang, Q., & Xie, H. (2005). Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis, 39(1-2), 217-224. https://doi.org/10.1016/j.jpba.2005.03.041

@article{6d8a8a6485a7420fae8a3903c95d68c4,

title = "Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies",

abstract = "To support the pharmacokinetic and bioavailability study of an extended-release loratadine (LOR)/pseudoephedrine sulfate (PES) tablet, a high performance liquid chromatographic-electrospray ionisation-mass spectrometric method (LC-MS) was developed for the simultaneous determination of LOR and PES in human plasma. Diazepam (DP) and phenylpropanolamine (PPA) were used as internal standards for LOR and PES, respectively. Analytes were extracted from alkalized human plasma by liquid/liquid extraction using ethyl ether. Chromatographic separation was performed on an ODS column at flow rate of 0.2 ml/min. The total chromatographic run time was 10.5 min with the retention time of 7.1 min and 6.2 min for LOR and DP, respectively, and 2.2 min for both of PES and PPA. The LOQ was 10 pg/ml and 50 pg/ml for LOR and PES, respectively. The method is accurate and precise enough for its intended purpose.",

keywords = "LC-MS, Loratadine, Pharmacokinetics, Pseudoephedrine sulfate",

author = "Jianguo Sun and Guangji Wang and Wei Wang and Shuai Zhao and Yi Gu and Jinwen Zhang and Mingwen Huang and Fen Shao and Hao Li and Qi Zhang and Haitang Xie",

year = "2005",

month = sep,

day = "1",

doi = "10.1016/j.jpba.2005.03.041",

language = "英语",

volume = "39",

pages = "217--224",

journal = "Journal of Pharmaceutical and Biomedical Analysis",

issn = "0731-7085",

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}

Sun, J, Wang, G, Wang, W, Zhao, S, Gu, Y, Zhang, J, Huang, M, Shao, F, Li, H, Zhang, Q & Xie, H 2005, 'Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies', Journal of Pharmaceutical and Biomedical Analysis, 卷 39, 号码 1-2, 页码 217-224. https://doi.org/10.1016/j.jpba.2005.03.041

Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies. / Sun, Jianguo; Wang, Guangji; Wang, Wei 等.
在: Journal of Pharmaceutical and Biomedical Analysis, 卷 39, 号码 1-2, 01.09.2005, 页码 217-224.

科研成果: 期刊稿件 › 文章 › 同行评审

TY - JOUR

T1 - Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies

AU - Sun, Jianguo

AU - Wang, Guangji

AU - Wang, Wei

AU - Zhao, Shuai

AU - Gu, Yi

AU - Zhang, Jinwen

AU - Huang, Mingwen

AU - Shao, Fen

AU - Li, Hao

AU - Zhang, Qi

AU - Xie, Haitang

PY - 2005/9/1

Y1 - 2005/9/1

N2 - To support the pharmacokinetic and bioavailability study of an extended-release loratadine (LOR)/pseudoephedrine sulfate (PES) tablet, a high performance liquid chromatographic-electrospray ionisation-mass spectrometric method (LC-MS) was developed for the simultaneous determination of LOR and PES in human plasma. Diazepam (DP) and phenylpropanolamine (PPA) were used as internal standards for LOR and PES, respectively. Analytes were extracted from alkalized human plasma by liquid/liquid extraction using ethyl ether. Chromatographic separation was performed on an ODS column at flow rate of 0.2 ml/min. The total chromatographic run time was 10.5 min with the retention time of 7.1 min and 6.2 min for LOR and DP, respectively, and 2.2 min for both of PES and PPA. The LOQ was 10 pg/ml and 50 pg/ml for LOR and PES, respectively. The method is accurate and precise enough for its intended purpose.

AB - To support the pharmacokinetic and bioavailability study of an extended-release loratadine (LOR)/pseudoephedrine sulfate (PES) tablet, a high performance liquid chromatographic-electrospray ionisation-mass spectrometric method (LC-MS) was developed for the simultaneous determination of LOR and PES in human plasma. Diazepam (DP) and phenylpropanolamine (PPA) were used as internal standards for LOR and PES, respectively. Analytes were extracted from alkalized human plasma by liquid/liquid extraction using ethyl ether. Chromatographic separation was performed on an ODS column at flow rate of 0.2 ml/min. The total chromatographic run time was 10.5 min with the retention time of 7.1 min and 6.2 min for LOR and DP, respectively, and 2.2 min for both of PES and PPA. The LOQ was 10 pg/ml and 50 pg/ml for LOR and PES, respectively. The method is accurate and precise enough for its intended purpose.

KW - LC-MS

KW - Loratadine

KW - Pharmacokinetics

KW - Pseudoephedrine sulfate

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U2 - 10.1016/j.jpba.2005.03.041

DO - 10.1016/j.jpba.2005.03.041

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AN - SCOPUS:23444451450

SN - 0731-7085

VL - 39

SP - 217

EP - 224

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

IS - 1-2

ER -

Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies

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