Solubility measurement and correlation of uridine-5'-monophosphate disodium in ethanol-aqueous mixture

The built-in dual circuit laser detector was applied to measure the solubility of uridine-5'-monophosphate disodium salt (5'-UMPNa₂) in deionized water and ethanol-aqueous mixture at 293.2-318.2 K, in which the mass fraction of ethanol was varied from zero to 0.65. It indicates that the solubility increases with the increase of temperature and decreases with the increase of ethanol mass fraction. The experimental data were correlated in the models of R-K equation, λh equation and Wilson equation respectively, and the least square regression method was used for parameters estimation. The results indicate that λh equation describes the solubility data best, and the parameters λ and h are expressed in the function of ethanol mass fraction for interpolation calculation, whose accuracy can meet the engineering requirement.