Study on the acute toxicity of chemicals to fish by QSAR model

To manage the use of chemicals, to predict the toxicity of unknown compounds is needed. A series of acute toxicity of environmental chemicals to fish is predicted by Quantitative structure-activity relationship (QSAR) method. The progress in QSAR research, methodology, mathematical modeling and molecular descriptors is reviewed. Finally, the octanol/water partition coefficient method is used to summarize the acute toxicity of 119 compounds to fish, which can provide significant value of predicting the acute toxicity of environmental chemicals.