Sulfinate-Promoted Defluorinative Cyclization of Polyfluoroalkyl Tetralones Enabled by Photocatalysis

Ming Yao Tang, Xiao Ying Li, Xiao Xiao Sun, Hao Xu, Mengtao Ma, Zhi Liang Shen, Xue Qiang Chu

科研成果: 期刊稿件文章同行评审

4 引用 (Scopus)

摘要

A Ru-catalyzed defluorinative cyclization of polyfluoroalkyl tetralones has been developed under visible-light irradiation for the precise assembly of γ-pyrones featuring α-perfluoroalkyl and β-fluorine substituents. Selective functionalization of five C(sp3)-F bonds at three carbon sites on the perfluoroalkyl chain provides a new mode for utilizing polyfluorides as versatile synthons to access difficult-to-obtain heterocyclic scaffolds. Moreover, the sulfinate salt serves dual roles as an oxygen source for creating the carbonyl group and as a defluorinating promoter.

源语言英语
期刊Organic Letters
DOI
出版状态已接受/待刊 - 2025

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