Synthesis of Benzofuro[3,2- c ]isoquinolines through Anionic Intramolecular Cyclization

Bo Yang, Peng Fei Dai, Jian Ping Qu, Yan Biao Kang

科研成果: 期刊稿件文章同行评审

摘要

Benzofuro[3,2- c ]isoquinolines are among the typical tetraheterocycles. The synthesis of benzofuro[3,2- c ]isoquinoline derivatives in the presence of a catalytic amount of KOH has been developed. A variety of substituents could be tolerated. The base (KOH) works as a catalyst. A gram-scale synthesis was performed. Control experiments confirmed that a cascade anionic annulation is involved rather than a radical cyclization.

源语言英语
期刊Synthesis (Germany)
DOI
出版状态已接受/待刊 - 2025

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