The Michael Addition of Indole to α,β-Unsaturated Ketones Catalyzed by Iodine at Room Temperature

Shun Yi Wang; Shun Jun Ji; Teck Peng Loh

doi:10.1055/s-2003-42105

The Michael Addition of Indole to α,β-Unsaturated Ketones Catalyzed by Iodine at Room Temperature

Shun Yi Wang, Shun Jun Ji, Teck Peng Loh

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124 引用（Scopus）

摘要

Indole undergoes conjugate addition with α,β-unsaturated ketones by means of alkylation of indole in the presence of a catalytic amount of molecular I₂ at room temperature to afford the corresponding adduct in excellent yields (up to 96%). The substitution on the indole nucleus occurred exclusively at the 3-position. N-alkylation products have not been observed.

源语言	英语
页（从-至）	2377-2379
页数	3
期刊	Synlett
期	15
DOI	https://doi.org/10.1055/s-2003-42105
出版状态	已出版 - 2003
已对外发布	是

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10.1055/s-2003-42105

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title = "The Michael Addition of Indole to α,β-Unsaturated Ketones Catalyzed by Iodine at Room Temperature",

abstract = "Indole undergoes conjugate addition with α,β-unsaturated ketones by means of alkylation of indole in the presence of a catalytic amount of molecular I2 at room temperature to afford the corresponding adduct in excellent yields (up to 96%). The substitution on the indole nucleus occurred exclusively at the 3-position. N-alkylation products have not been observed.",

keywords = "Indoles, Michael reaction, Molecular iodine",

author = "Wang, {Shun Yi} and Ji, {Shun Jun} and Loh, {Teck Peng}",

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T1 - The Michael Addition of Indole to α,β-Unsaturated Ketones Catalyzed by Iodine at Room Temperature

AU - Wang, Shun Yi

AU - Ji, Shun Jun

AU - Loh, Teck Peng

PY - 2003

Y1 - 2003

N2 - Indole undergoes conjugate addition with α,β-unsaturated ketones by means of alkylation of indole in the presence of a catalytic amount of molecular I2 at room temperature to afford the corresponding adduct in excellent yields (up to 96%). The substitution on the indole nucleus occurred exclusively at the 3-position. N-alkylation products have not been observed.

AB - Indole undergoes conjugate addition with α,β-unsaturated ketones by means of alkylation of indole in the presence of a catalytic amount of molecular I2 at room temperature to afford the corresponding adduct in excellent yields (up to 96%). The substitution on the indole nucleus occurred exclusively at the 3-position. N-alkylation products have not been observed.

KW - Indoles

KW - Michael reaction

KW - Molecular iodine

UR - http://www.scopus.com/inward/record.url?scp=0346749663&partnerID=8YFLogxK

U2 - 10.1055/s-2003-42105

DO - 10.1055/s-2003-42105

M3 - 文章

AN - SCOPUS:0346749663

SN - 0936-5214

SP - 2377

EP - 2379

JO - Synlett

JF - Synlett

IS - 15

ER -

The Michael Addition of Indole to α,β-Unsaturated Ketones Catalyzed by Iodine at Room Temperature

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