Titanium(IV)-Mediated Ring-Opening/Dehydroxylative Cross-Coupling of Diaryl-Substituted Methanols with Cyclopropanol Derivatives

Si Xuan Zhang, Yan Ding, Jun Jie Wang, Chuanji Shen, Xiaocong Zhou, Xue Qiang Chu, Mengtao Ma, Zhi Liang Shen

科研成果: 期刊稿件文章同行评审

4 引用 (Scopus)

摘要

A titanium(IV)-mediated ring-opening/dehydroxylative cross-coupling of diaryl-substituted methanols with a cyclopropanol derivative was developed. The reactions proceeded efficiently to provide synthetically useful γ,γ-diaryl esters in moderate to good yields, which could be applied to the functionalization of complex molecules derived from bioactive fenofibrate and isoxepac and the synthesis of a precursor of Zoloft.

源语言英语
页(从-至)15753-15760
页数8
期刊Journal of Organic Chemistry
86
21
DOI
出版状态已出版 - 5 11月 2021

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