α-Trideuteration of methylarenes

Lin Tie; Xiang Huan Shan; Jian Ping Qu; Yan Biao Kang

doi:10.1039/d1qo00265a

α-Trideuteration of methylarenes

Lin Tie, Xiang Huan Shan, Jian Ping Qu, Yan Biao Kang

School of Chemistry and Moleculai Engineering

University of Science and Technology of China

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

An efficient and practical transition metal free α-trideuteration of methylarenes was developed. This process proceeds via an inexpensive base, such as sodium hydroxide or potassium tert-butoxide, prompted deprotonation and reprotonation of methylarenes in DMSO-d6 solvent. The reaction is applicable to a wide range of methylarenes and allows the introduction of a trideuteriomethyl group to aromatics with excellent selectivity.

Original language	English
Pages (from-to)	2981-2984
Number of pages	4
Journal	Organic Chemistry Frontiers
Volume	8
Issue number	12
DOIs	https://doi.org/10.1039/d1qo00265a
State	Published - 21 Jun 2021

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title = "α-Trideuteration of methylarenes",

abstract = "An efficient and practical transition metal free α-trideuteration of methylarenes was developed. This process proceeds via an inexpensive base, such as sodium hydroxide or potassium tert-butoxide, prompted deprotonation and reprotonation of methylarenes in DMSO-d6 solvent. The reaction is applicable to a wide range of methylarenes and allows the introduction of a trideuteriomethyl group to aromatics with excellent selectivity.",

author = "Lin Tie and Shan, {Xiang Huan} and Qu, {Jian Ping} and Kang, {Yan Biao}",

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AU - Tie, Lin

AU - Shan, Xiang Huan

AU - Qu, Jian Ping

AU - Kang, Yan Biao

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Y1 - 2021/6/21

N2 - An efficient and practical transition metal free α-trideuteration of methylarenes was developed. This process proceeds via an inexpensive base, such as sodium hydroxide or potassium tert-butoxide, prompted deprotonation and reprotonation of methylarenes in DMSO-d6 solvent. The reaction is applicable to a wide range of methylarenes and allows the introduction of a trideuteriomethyl group to aromatics with excellent selectivity.

AB - An efficient and practical transition metal free α-trideuteration of methylarenes was developed. This process proceeds via an inexpensive base, such as sodium hydroxide or potassium tert-butoxide, prompted deprotonation and reprotonation of methylarenes in DMSO-d6 solvent. The reaction is applicable to a wide range of methylarenes and allows the introduction of a trideuteriomethyl group to aromatics with excellent selectivity.

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M3 - 文章

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SN - 2052-4110

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SP - 2981

EP - 2984

JO - Organic Chemistry Frontiers

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ER -

α-Trideuteration of methylarenes

Abstract

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