α-Trideuteration of methylarenes

Lin Tie; Xiang Huan Shan; Jian Ping Qu; Yan Biao Kang

doi:10.1039/d1qo00265a

α-Trideuteration of methylarenes

Lin Tie, Xiang Huan Shan, Jian Ping Qu, Yan Biao Kang

化学与分子工程学院

University of Science and Technology of China

科研成果: 期刊稿件 › 文章 › 同行评审

19 引用（Scopus）

摘要

An efficient and practical transition metal free α-trideuteration of methylarenes was developed. This process proceeds via an inexpensive base, such as sodium hydroxide or potassium tert-butoxide, prompted deprotonation and reprotonation of methylarenes in DMSO-d6 solvent. The reaction is applicable to a wide range of methylarenes and allows the introduction of a trideuteriomethyl group to aromatics with excellent selectivity.

源语言	英语
页（从-至）	2981-2984
页数	4
期刊	Organic Chemistry Frontiers
卷	8
期	12
DOI	https://doi.org/10.1039/d1qo00265a
出版状态	已出版 - 21 6月 2021

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10.1039/d1qo00265a

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α-Trideuteration of methylarenes

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