β-C(sp3)-H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group

Tetsuya Toba; Yi Hu; Anh T. Tran; Jin Quan Yu

doi:10.1021/acs.orglett.5b02900

β-C(sp³)-H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group

Tetsuya Toba, Yi Hu, Anh T. Tran, Jin Quan Yu

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The Pd(II)-catalyzed arylation of unactivated β-C(sp³)-H bonds in α-hydroxy aliphatic acid with a variety of aryl iodides was developed utilizing an amino acid auxiliary as a directing group. This protocol provides access to biologically active β-arylated-α-hydroxy acid derivatives.

Original language	English
Pages (from-to)	5966-5969
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	24
DOIs	https://doi.org/10.1021/acs.orglett.5b02900
State	Published - 4 Dec 2015

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title = "β-C(sp3)-H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group",

abstract = "The Pd(II)-catalyzed arylation of unactivated β-C(sp3)-H bonds in α-hydroxy aliphatic acid with a variety of aryl iodides was developed utilizing an amino acid auxiliary as a directing group. This protocol provides access to biologically active β-arylated-α-hydroxy acid derivatives.",

author = "Tetsuya Toba and Yi Hu and Tran, {Anh T.} and Yu, {Jin Quan}",

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AU - Hu, Yi

AU - Tran, Anh T.

AU - Yu, Jin Quan

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AB - The Pd(II)-catalyzed arylation of unactivated β-C(sp3)-H bonds in α-hydroxy aliphatic acid with a variety of aryl iodides was developed utilizing an amino acid auxiliary as a directing group. This protocol provides access to biologically active β-arylated-α-hydroxy acid derivatives.

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JO - Organic Letters

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β-C(sp³)-H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group

Abstract

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