1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative difunctionalization of styrenes: Microfluidic synthesis of pentafluorophenoxy ketone

Jia Xu; Jiawei Hua; Mixue Bian; Yuguang Li; Wei He; Zhao Yang; Chengkou Liu; Zheng Fang; Kai Guo

doi:10.1016/j.tetlet.2021.152876

1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative difunctionalization of styrenes: Microfluidic synthesis of pentafluorophenoxy ketone

Jia Xu, Jiawei Hua, Mixue Bian, Yuguang Li, Wei He, Zhao Yang, Chengkou Liu, Zheng Fang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A practical and mild synthesis of pentafluorophenoxy ketone in a continuous flow microfluidic reactor has been developed through 1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative coupling of styrenes with pentafluorophenol. Moreover, a series of pentafluorophenoxy ketone products were provided in moderate to good yields under metal-free conditions. A magnifying continuous flow system was erected to verify the appliance of this method.

Original language	English
Article number	152876
Journal	Tetrahedron Letters
Volume	67
DOIs	https://doi.org/10.1016/j.tetlet.2021.152876
State	Published - 16 Mar 2021

Keywords

Continuous flow system
DBH/DMSO
Metal-free
Pentafluorophenoxy ketone

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10.1016/j.tetlet.2021.152876

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title = "1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative difunctionalization of styrenes: Microfluidic synthesis of pentafluorophenoxy ketone",

abstract = "A practical and mild synthesis of pentafluorophenoxy ketone in a continuous flow microfluidic reactor has been developed through 1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative coupling of styrenes with pentafluorophenol. Moreover, a series of pentafluorophenoxy ketone products were provided in moderate to good yields under metal-free conditions. A magnifying continuous flow system was erected to verify the appliance of this method.",

keywords = "Continuous flow system, DBH/DMSO, Metal-free, Pentafluorophenoxy ketone",

author = "Jia Xu and Jiawei Hua and Mixue Bian and Yuguang Li and Wei He and Zhao Yang and Chengkou Liu and Zheng Fang and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

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doi = "10.1016/j.tetlet.2021.152876",

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T1 - 1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative difunctionalization of styrenes

T2 - Microfluidic synthesis of pentafluorophenoxy ketone

AU - Xu, Jia

AU - Hua, Jiawei

AU - Bian, Mixue

AU - Li, Yuguang

AU - He, Wei

AU - Yang, Zhao

AU - Liu, Chengkou

AU - Fang, Zheng

AU - Guo, Kai

PY - 2021/3/16

Y1 - 2021/3/16

N2 - A practical and mild synthesis of pentafluorophenoxy ketone in a continuous flow microfluidic reactor has been developed through 1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative coupling of styrenes with pentafluorophenol. Moreover, a series of pentafluorophenoxy ketone products were provided in moderate to good yields under metal-free conditions. A magnifying continuous flow system was erected to verify the appliance of this method.

AB - A practical and mild synthesis of pentafluorophenoxy ketone in a continuous flow microfluidic reactor has been developed through 1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative coupling of styrenes with pentafluorophenol. Moreover, a series of pentafluorophenoxy ketone products were provided in moderate to good yields under metal-free conditions. A magnifying continuous flow system was erected to verify the appliance of this method.

KW - Continuous flow system

KW - DBH/DMSO

KW - Metal-free

KW - Pentafluorophenoxy ketone

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U2 - 10.1016/j.tetlet.2021.152876

DO - 10.1016/j.tetlet.2021.152876

M3 - 文章

AN - SCOPUS:85101076562

SN - 0040-4039

VL - 67

JO - Tetrahedron Letters

JF - Tetrahedron Letters

M1 - 152876

ER -

1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative difunctionalization of styrenes: Microfluidic synthesis of pentafluorophenoxy ketone

Abstract

Keywords

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