1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative difunctionalization of styrenes: Microfluidic synthesis of pentafluorophenoxy ketone

Jia Xu, Jiawei Hua, Mixue Bian, Yuguang Li, Wei He, Zhao Yang, Chengkou Liu, Zheng Fang, Kai Guo

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摘要

A practical and mild synthesis of pentafluorophenoxy ketone in a continuous flow microfluidic reactor has been developed through 1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative coupling of styrenes with pentafluorophenol. Moreover, a series of pentafluorophenoxy ketone products were provided in moderate to good yields under metal-free conditions. A magnifying continuous flow system was erected to verify the appliance of this method.

源语言英语
文章编号152876
期刊Tetrahedron Letters
67
DOI
出版状态已出版 - 16 3月 2021

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