A highly stereoselective synthesis of β-trifluoromethylated homoallylic alcohols in water

T. P. Loh; X. R. Li

doi:10.1002/anie.199709801

A highly stereoselective synthesis of β-trifluoromethylated homoallylic alcohols in water

T. P. Loh, X. R. Li

National University of Singapore

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A tin-mediated, indium trichloride promoted allylation reaction provided β-trifluoromethylated homoallylic alcohols, the building blocks of biologically active substances, in high yields and excellent stereoselectivity. Since the syntheses can be carried out in water, the reactive OH groups do not need to be protected, and even compounds that are insoluble in organic solvents can be used.

Original language	English
Pages (from-to)	980-982
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	36
Issue number	9
DOIs	https://doi.org/10.1002/anie.199709801
State	Published - 1997
Externally published	Yes

Keywords

aldehydes
allylation
fluorine
indium
tin

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10.1002/anie.199709801

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abstract = "A tin-mediated, indium trichloride promoted allylation reaction provided β-trifluoromethylated homoallylic alcohols, the building blocks of biologically active substances, in high yields and excellent stereoselectivity. Since the syntheses can be carried out in water, the reactive OH groups do not need to be protected, and even compounds that are insoluble in organic solvents can be used.",

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AB - A tin-mediated, indium trichloride promoted allylation reaction provided β-trifluoromethylated homoallylic alcohols, the building blocks of biologically active substances, in high yields and excellent stereoselectivity. Since the syntheses can be carried out in water, the reactive OH groups do not need to be protected, and even compounds that are insoluble in organic solvents can be used.

KW - aldehydes

KW - allylation

KW - fluorine

KW - indium

KW - tin

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DO - 10.1002/anie.199709801

M3 - 文章

AN - SCOPUS:0030941386

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ER -

A highly stereoselective synthesis of β-trifluoromethylated homoallylic alcohols in water

Abstract

Keywords

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