A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

Leilei Rui; Yudong Xue; Yong Wang; Yun Gao; Weian Zhang

doi:10.1039/C7CC00950J

A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

Leilei Rui, Yudong Xue, Yong Wang, Yun Gao, Weian Zhang

COLLEGE OF CHEMICAL ENGINEERING

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host-guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (¹O₂) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.

Original language	English
Pages (from-to)	3126-3129
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	21
DOIs	https://doi.org/10.1039/C7CC00950J
State	Published - 2017

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abstract = "A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host-guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (1O2) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.",

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AU - Rui, Leilei

AU - Xue, Yudong

AU - Wang, Yong

AU - Gao, Yun

AU - Zhang, Weian

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host-guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (1O2) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.

AB - A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host-guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (1O2) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.

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U2 - 10.1039/C7CC00950J

DO - 10.1039/C7CC00950J

M3 - 文章

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AN - SCOPUS:85014970157

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JO - Chemical Communications

JF - Chemical Communications

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ER -

A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

Abstract

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