A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

Leilei Rui; Yudong Xue; Yong Wang; Yun Gao; Weian Zhang

doi:10.1039/C7CC00950J

A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

Leilei Rui, Yudong Xue, Yong Wang, Yun Gao, Weian Zhang

化工学院

East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

55 引用（Scopus）

摘要

A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host-guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (¹O₂) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.

源语言	英语
页（从-至）	3126-3129
页数	4
期刊	Chemical Communications
卷	53
期	21
DOI	https://doi.org/10.1039/C7CC00950J
出版状态	已出版 - 2017

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AU - Xue, Yudong

AU - Wang, Yong

AU - Gao, Yun

AU - Zhang, Weian

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A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

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