TY - JOUR
T1 - A mussel-inspired poly(γ-glutamic acid) tissue adhesive with high wet strength for wound closure
AU - Chen, Wei
AU - Wang, Rui
AU - Xu, Tingting
AU - Ma, Xuebin
AU - Yao, Zhong
AU - Chi, Bo
AU - Xu, Hong
N1 - Publisher Copyright:
© 2017 The Royal Society of Chemistry.
PY - 2017
Y1 - 2017
N2 - Injectable hydrogels are promising candidates for adhesives because of their ease of administration, minimal invasion, and biocompatibility. While developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility have still been a significant challenge. Herein, inspired from nature, we report a novel mussel-inspired tissue-adhesive hydrogel composed of poly(γ-glutamic acid) and dopamine (γ-PGA-DA) that can bond tissues well and stop bleeding in a wet environment by improving its tissue adhesiveness via a horseradish peroxidase-mediated reaction. The hydrogel exhibited 10-12 fold stronger wet tissue adhesion strength (58.2 kPa) over the clinically used fibrin glue and more effective hemostatic ability following liver impalement in animal models (41.2% reduction in the average amount of bleeding compared with fibrin glue). In addition, the hydrogels demonstrated controlled gelation time, swelling ratio, microscopic morphology, biodegradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility. The overall results suggest that the γ-PGA-DA hydrogels can be considerably applied as promising wet-resistant adhesives and hemostatic materials.
AB - Injectable hydrogels are promising candidates for adhesives because of their ease of administration, minimal invasion, and biocompatibility. While developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility have still been a significant challenge. Herein, inspired from nature, we report a novel mussel-inspired tissue-adhesive hydrogel composed of poly(γ-glutamic acid) and dopamine (γ-PGA-DA) that can bond tissues well and stop bleeding in a wet environment by improving its tissue adhesiveness via a horseradish peroxidase-mediated reaction. The hydrogel exhibited 10-12 fold stronger wet tissue adhesion strength (58.2 kPa) over the clinically used fibrin glue and more effective hemostatic ability following liver impalement in animal models (41.2% reduction in the average amount of bleeding compared with fibrin glue). In addition, the hydrogels demonstrated controlled gelation time, swelling ratio, microscopic morphology, biodegradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility. The overall results suggest that the γ-PGA-DA hydrogels can be considerably applied as promising wet-resistant adhesives and hemostatic materials.
UR - http://www.scopus.com/inward/record.url?scp=85025105177&partnerID=8YFLogxK
U2 - 10.1039/c7tb00813a
DO - 10.1039/c7tb00813a
M3 - 文章
AN - SCOPUS:85025105177
SN - 2050-750X
VL - 5
SP - 5668
EP - 5678
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 28
ER -