A mussel-inspired poly(γ-glutamic acid) tissue adhesive with high wet strength for wound closure

Wei Chen, Rui Wang, Tingting Xu, Xuebin Ma, Zhong Yao, Bo Chi, Hong Xu

科研成果: 期刊稿件文章同行评审

102 引用 (Scopus)

摘要

Injectable hydrogels are promising candidates for adhesives because of their ease of administration, minimal invasion, and biocompatibility. While developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility have still been a significant challenge. Herein, inspired from nature, we report a novel mussel-inspired tissue-adhesive hydrogel composed of poly(γ-glutamic acid) and dopamine (γ-PGA-DA) that can bond tissues well and stop bleeding in a wet environment by improving its tissue adhesiveness via a horseradish peroxidase-mediated reaction. The hydrogel exhibited 10-12 fold stronger wet tissue adhesion strength (58.2 kPa) over the clinically used fibrin glue and more effective hemostatic ability following liver impalement in animal models (41.2% reduction in the average amount of bleeding compared with fibrin glue). In addition, the hydrogels demonstrated controlled gelation time, swelling ratio, microscopic morphology, biodegradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility. The overall results suggest that the γ-PGA-DA hydrogels can be considerably applied as promising wet-resistant adhesives and hemostatic materials.

源语言英语
页(从-至)5668-5678
页数11
期刊Journal of Materials Chemistry B
5
28
DOI
出版状态已出版 - 2017

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