A two-step continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles under metal- and azide-free conditions

Jiajia Gu; Zheng Fang; Zhao Yang; Xin Li; Ning Zhu; Li Wan; Ping Wei; Kai Guo

doi:10.1039/c6ra19022g

A two-step continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles under metal- and azide-free conditions

Jiajia Gu, Zheng Fang, Zhao Yang, Xin Li, Ning Zhu, Li Wan, Ping Wei, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A green, general and efficient I₂/TBHP mediated synthetic method toward 1,4-disubstituted 1,2,3-triazoles via the reactions of acetophenones, tosylhydrazine and anilines within 35 min in a two-step continuous flow system has been developed. The reaction proceeds smoothly to afford 1,4-disubstituted 1,2,3-triazoles in moderate to good yield under metal- and azide-free conditions by using I₂ as a catalyst.

Original language	English
Pages (from-to)	89073-89079
Number of pages	7
Journal	RSC Advances
Volume	6
Issue number	92
DOIs	https://doi.org/10.1039/c6ra19022g
State	Published - 2016

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title = "A two-step continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles under metal- and azide-free conditions",

abstract = "A green, general and efficient I2/TBHP mediated synthetic method toward 1,4-disubstituted 1,2,3-triazoles via the reactions of acetophenones, tosylhydrazine and anilines within 35 min in a two-step continuous flow system has been developed. The reaction proceeds smoothly to afford 1,4-disubstituted 1,2,3-triazoles in moderate to good yield under metal- and azide-free conditions by using I2 as a catalyst.",

author = "Jiajia Gu and Zheng Fang and Zhao Yang and Xin Li and Ning Zhu and Li Wan and Ping Wei and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

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T1 - A two-step continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles under metal- and azide-free conditions

AU - Gu, Jiajia

AU - Fang, Zheng

AU - Yang, Zhao

AU - Li, Xin

AU - Zhu, Ning

AU - Wan, Li

AU - Wei, Ping

AU - Guo, Kai

PY - 2016

Y1 - 2016

N2 - A green, general and efficient I2/TBHP mediated synthetic method toward 1,4-disubstituted 1,2,3-triazoles via the reactions of acetophenones, tosylhydrazine and anilines within 35 min in a two-step continuous flow system has been developed. The reaction proceeds smoothly to afford 1,4-disubstituted 1,2,3-triazoles in moderate to good yield under metal- and azide-free conditions by using I2 as a catalyst.

AB - A green, general and efficient I2/TBHP mediated synthetic method toward 1,4-disubstituted 1,2,3-triazoles via the reactions of acetophenones, tosylhydrazine and anilines within 35 min in a two-step continuous flow system has been developed. The reaction proceeds smoothly to afford 1,4-disubstituted 1,2,3-triazoles in moderate to good yield under metal- and azide-free conditions by using I2 as a catalyst.

UR - http://www.scopus.com/inward/record.url?scp=84988568607&partnerID=8YFLogxK

U2 - 10.1039/c6ra19022g

DO - 10.1039/c6ra19022g

M3 - 文章

AN - SCOPUS:84988568607

SN - 2046-2069

VL - 6

SP - 89073

EP - 89079

JO - RSC Advances

JF - RSC Advances

IS - 92

ER -

A two-step continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles under metal- and azide-free conditions

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