A two-step continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles under metal- and azide-free conditions

Jiajia Gu, Zheng Fang, Zhao Yang, Xin Li, Ning Zhu, Li Wan, Ping Wei, Kai Guo

科研成果: 期刊稿件文章同行评审

17 引用 (Scopus)

摘要

A green, general and efficient I2/TBHP mediated synthetic method toward 1,4-disubstituted 1,2,3-triazoles via the reactions of acetophenones, tosylhydrazine and anilines within 35 min in a two-step continuous flow system has been developed. The reaction proceeds smoothly to afford 1,4-disubstituted 1,2,3-triazoles in moderate to good yield under metal- and azide-free conditions by using I2 as a catalyst.

源语言英语
页(从-至)89073-89079
页数7
期刊RSC Advances
6
92
DOI
出版状态已出版 - 2016

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