Aldol reaction under solvent-free conditions: Highly stereoselective synthesis of 1,3-amino alcohols

Teck Peng Loh; Jing Mei Huang; Swee Hock Goh; Jagadese J. Vittal

doi:10.1021/ol000042s

Aldol reaction under solvent-free conditions: Highly stereoselective synthesis of 1,3-amino alcohols

Teck Peng Loh, Jing Mei Huang, Swee Hock Goh, Jagadese J. Vittal

National University of Singapore

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

(formula presented) A method for the highly stereoselective synthesis of 1,3-amino alcohols based on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto ester (R,S)-1 under solvent-free conditions has been developed. The high selectivity observed can be explained on the basis of the shielding of one face by a remote substituent.

Original language	English
Pages (from-to)	1291-1294
Number of pages	4
Journal	Organic Letters
Volume	2
Issue number	9
DOIs	https://doi.org/10.1021/ol000042s
State	Published - 4 May 2000
Externally published	Yes

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10.1021/ol000042s

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title = "Aldol reaction under solvent-free conditions: Highly stereoselective synthesis of 1,3-amino alcohols",

abstract = "(formula presented) A method for the highly stereoselective synthesis of 1,3-amino alcohols based on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto ester (R,S)-1 under solvent-free conditions has been developed. The high selectivity observed can be explained on the basis of the shielding of one face by a remote substituent.",

author = "Loh, {Teck Peng} and Huang, {Jing Mei} and Goh, {Swee Hock} and Vittal, {Jagadese J.}",

year = "2000",

month = may,

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doi = "10.1021/ol000042s",

language = "英语",

volume = "2",

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journal = "Organic Letters",

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T1 - Aldol reaction under solvent-free conditions

T2 - Highly stereoselective synthesis of 1,3-amino alcohols

AU - Loh, Teck Peng

AU - Huang, Jing Mei

AU - Goh, Swee Hock

AU - Vittal, Jagadese J.

PY - 2000/5/4

Y1 - 2000/5/4

N2 - (formula presented) A method for the highly stereoselective synthesis of 1,3-amino alcohols based on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto ester (R,S)-1 under solvent-free conditions has been developed. The high selectivity observed can be explained on the basis of the shielding of one face by a remote substituent.

AB - (formula presented) A method for the highly stereoselective synthesis of 1,3-amino alcohols based on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto ester (R,S)-1 under solvent-free conditions has been developed. The high selectivity observed can be explained on the basis of the shielding of one face by a remote substituent.

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U2 - 10.1021/ol000042s

DO - 10.1021/ol000042s

M3 - 文章

AN - SCOPUS:0001435657

SN - 1523-7060

VL - 2

SP - 1291

EP - 1294

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Aldol reaction under solvent-free conditions: Highly stereoselective synthesis of 1,3-amino alcohols

Abstract

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