Abstract
A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.
Original language | English |
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Pages (from-to) | 15020-15023 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 56 |
Issue number | 95 |
DOIs | |
State | Published - 11 Dec 2020 |