An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization

Shuguang Zhou, Duan Yang Liu, Suo Wang, Jie Sheng Tian, Teck Peng Loh

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.

Original languageEnglish
Pages (from-to)15020-15023
Number of pages4
JournalChemical Communications
Volume56
Issue number95
DOIs
StatePublished - 11 Dec 2020

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