An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization

Shuguang Zhou; Duan Yang Liu; Suo Wang; Jie Sheng Tian; Teck Peng Loh

doi:10.1039/d0cc06834a

An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization

Shuguang Zhou, Duan Yang Liu, Suo Wang, Jie Sheng Tian, Teck Peng Loh

化学与分子工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

25 引用（Scopus）

摘要

A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.

源语言	英语
页（从-至）	15020-15023
页数	4
期刊	Chemical Communications
卷	56
期	95
DOI	https://doi.org/10.1039/d0cc06834a
出版状态	已出版 - 11 12月 2020

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abstract = "A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.",

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AU - Loh, Teck Peng

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AB - A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.

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An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization

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