Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease

Xiaoqiang Chen; Jiangli Fan; Xiaojun Peng; Jingyun Wang; Shiguo Sun; Rong Zhang; Tong Wu; Fei Zhang; Jianfeng Liu; Fen Wang; Saijian Ma

doi:10.1016/j.bmcl.2009.06.003

Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease

Xiaoqiang Chen, Jiangli Fan, Xiaojun Peng, Jingyun Wang, Shiguo Sun, Rong Zhang, Tong Wu, Fei Zhang, Jianfeng Liu, Fen Wang, Saijian Ma

Dalian University of Technology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage.

Original language	English
Pages (from-to)	4139-4142
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2009.06.003
State	Published - 1 Aug 2009
Externally published	Yes

Keywords

Artificial nuclease
Bisintercalator
Dinuclear Iron(III) complex

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10.1016/j.bmcl.2009.06.003

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title = "Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease",

abstract = "Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage.",

keywords = "Artificial nuclease, Bisintercalator, Dinuclear Iron(III) complex",

author = "Xiaoqiang Chen and Jiangli Fan and Xiaojun Peng and Jingyun Wang and Shiguo Sun and Rong Zhang and Tong Wu and Fei Zhang and Jianfeng Liu and Fen Wang and Saijian Ma",

year = "2009",

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doi = "10.1016/j.bmcl.2009.06.003",

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volume = "19",

pages = "4139--4142",

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TY - JOUR

T1 - Bisintercalator-containing dinuclear iron(III) complex

T2 - An efficient artificial nuclease

AU - Chen, Xiaoqiang

AU - Fan, Jiangli

AU - Peng, Xiaojun

AU - Wang, Jingyun

AU - Sun, Shiguo

AU - Zhang, Rong

AU - Wu, Tong

AU - Zhang, Fei

AU - Liu, Jianfeng

AU - Wang, Fen

AU - Ma, Saijian

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage.

AB - Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage.

KW - Artificial nuclease

KW - Bisintercalator

KW - Dinuclear Iron(III) complex

UR - http://www.scopus.com/inward/record.url?scp=67649946947&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.06.003

DO - 10.1016/j.bmcl.2009.06.003

M3 - 文章

C2 - 19539469

AN - SCOPUS:67649946947

SN - 0960-894X

VL - 19

SP - 4139

EP - 4142

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease

Abstract

Keywords

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