Continuous preparation for rifampicin

Xin Li; Zhuang Liu; Hao Qi; Zheng Fang; Siyu Huang; Shanshan Miao; Kai Guo

doi:10.1007/s41981-018-0017-2

Continuous preparation for rifampicin

Xin Li, Zhuang Liu, Hao Qi, Zheng Fang, Siyu Huang, Shanshan Miao, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

Original language	English
Pages (from-to)	129-138
Number of pages	10
Journal	Journal of Flow Chemistry
Volume	8
Issue number	3-4
DOIs	https://doi.org/10.1007/s41981-018-0017-2
State	Published - 1 Dec 2018

Keywords

Continuous flow synthesis
Coupling of reaction and separation
Rifampicin preparation

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10.1007/s41981-018-0017-2

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title = "Continuous preparation for rifampicin",

abstract = "To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.",

keywords = "Continuous flow synthesis, Coupling of reaction and separation, Rifampicin preparation",

author = "Xin Li and Zhuang Liu and Hao Qi and Zheng Fang and Siyu Huang and Shanshan Miao and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2018, Akad{\'e}miai Kiad{\'o}.",

year = "2018",

month = dec,

day = "1",

doi = "10.1007/s41981-018-0017-2",

language = "英语",

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TY - JOUR

T1 - Continuous preparation for rifampicin

AU - Li, Xin

AU - Liu, Zhuang

AU - Qi, Hao

AU - Fang, Zheng

AU - Huang, Siyu

AU - Miao, Shanshan

AU - Guo, Kai

PY - 2018/12/1

Y1 - 2018/12/1

N2 - To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

AB - To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

KW - Continuous flow synthesis

KW - Coupling of reaction and separation

KW - Rifampicin preparation

UR - http://www.scopus.com/inward/record.url?scp=85057878511&partnerID=8YFLogxK

U2 - 10.1007/s41981-018-0017-2

DO - 10.1007/s41981-018-0017-2

M3 - 文章

AN - SCOPUS:85057878511

SN - 2062-249X

VL - 8

SP - 129

EP - 138

JO - Journal of Flow Chemistry

JF - Journal of Flow Chemistry

IS - 3-4

ER -

Continuous preparation for rifampicin

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Keywords

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