Continuous preparation for rifampicin

Xin Li; Zhuang Liu; Hao Qi; Zheng Fang; Siyu Huang; Shanshan Miao; Kai Guo

doi:10.1007/s41981-018-0017-2

Continuous preparation for rifampicin

Xin Li, Zhuang Liu, Hao Qi, Zheng Fang, Siyu Huang, Shanshan Miao, Kai Guo

生物与制药工程学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

源语言	英语
页（从-至）	129-138
页数	10
期刊	Journal of Flow Chemistry
卷	8
期	3-4
DOI	https://doi.org/10.1007/s41981-018-0017-2
出版状态	已出版 - 1 12月 2018

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title = "Continuous preparation for rifampicin",

abstract = "To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.",

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author = "Xin Li and Zhuang Liu and Hao Qi and Zheng Fang and Siyu Huang and Shanshan Miao and Kai Guo",

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doi = "10.1007/s41981-018-0017-2",

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T1 - Continuous preparation for rifampicin

AU - Li, Xin

AU - Liu, Zhuang

AU - Qi, Hao

AU - Fang, Zheng

AU - Huang, Siyu

AU - Miao, Shanshan

AU - Guo, Kai

PY - 2018/12/1

Y1 - 2018/12/1

N2 - To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

AB - To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

KW - Continuous flow synthesis

KW - Coupling of reaction and separation

KW - Rifampicin preparation

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U2 - 10.1007/s41981-018-0017-2

DO - 10.1007/s41981-018-0017-2

M3 - 文章

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SN - 2062-249X

VL - 8

SP - 129

EP - 138

JO - Journal of Flow Chemistry

JF - Journal of Flow Chemistry

IS - 3-4

ER -

Continuous preparation for rifampicin

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