Copper-catalyzed three-component annulation toward pyrroles via the cleavage of two C-C bonds in 1,3-dicarbonyls

Gaochen Xu; Luchao Li; Binyan Xu; Zheng Fang; Jindian Duan; Kai Guo

doi:10.1039/d3cc02681g

Copper-catalyzed three-component annulation toward pyrroles via the cleavage of two C-C bonds in 1,3-dicarbonyls

Gaochen Xu, Luchao Li, Binyan Xu, Zheng Fang, Jindian Duan, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The first copper-catalyzed three-component annulation of α,β-unsaturated ketoximes, 1,3-dicarbonyls and paraformaldehyde has been documented. This novel strategy achieved the two C-C bond cleavage of 1,3-dicarbonyl compounds directly as a single-carbon synthon and provided a new and highly efficient method for the synthesis of 2,3-disubstituted pyrroles in moderate to good yields with broad functional group compatibility.

Original language	English
Pages (from-to)	10636-10639
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	71
DOIs	https://doi.org/10.1039/d3cc02681g
State	Published - 9 Aug 2023

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abstract = "The first copper-catalyzed three-component annulation of α,β-unsaturated ketoximes, 1,3-dicarbonyls and paraformaldehyde has been documented. This novel strategy achieved the two C-C bond cleavage of 1,3-dicarbonyl compounds directly as a single-carbon synthon and provided a new and highly efficient method for the synthesis of 2,3-disubstituted pyrroles in moderate to good yields with broad functional group compatibility.",

author = "Gaochen Xu and Luchao Li and Binyan Xu and Zheng Fang and Jindian Duan and Kai Guo",

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T1 - Copper-catalyzed three-component annulation toward pyrroles via the cleavage of two C-C bonds in 1,3-dicarbonyls

AU - Xu, Gaochen

AU - Li, Luchao

AU - Xu, Binyan

AU - Fang, Zheng

AU - Duan, Jindian

AU - Guo, Kai

PY - 2023/8/9

Y1 - 2023/8/9

N2 - The first copper-catalyzed three-component annulation of α,β-unsaturated ketoximes, 1,3-dicarbonyls and paraformaldehyde has been documented. This novel strategy achieved the two C-C bond cleavage of 1,3-dicarbonyl compounds directly as a single-carbon synthon and provided a new and highly efficient method for the synthesis of 2,3-disubstituted pyrroles in moderate to good yields with broad functional group compatibility.

AB - The first copper-catalyzed three-component annulation of α,β-unsaturated ketoximes, 1,3-dicarbonyls and paraformaldehyde has been documented. This novel strategy achieved the two C-C bond cleavage of 1,3-dicarbonyl compounds directly as a single-carbon synthon and provided a new and highly efficient method for the synthesis of 2,3-disubstituted pyrroles in moderate to good yields with broad functional group compatibility.

UR - http://www.scopus.com/inward/record.url?scp=85169292273&partnerID=8YFLogxK

U2 - 10.1039/d3cc02681g

DO - 10.1039/d3cc02681g

M3 - 文章

C2 - 37580978

AN - SCOPUS:85169292273

SN - 1359-7345

VL - 59

SP - 10636

EP - 10639

JO - Chemical Communications

JF - Chemical Communications

IS - 71

ER -

Copper-catalyzed three-component annulation toward pyrroles via the cleavage of two C-C bonds in 1,3-dicarbonyls

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