Cu-catalyzed direct C-H bond functionalization: A regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles

Zengyang Xie, Xiaojun Zhu, Yangfan Guan, Dunru Zhu, Hongwen Hu, Chen Lin, Yi Pan, Juli Jiang, Leyong Wang

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4- triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed.

Original languageEnglish
Pages (from-to)1390-1398
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number8
DOIs
StatePublished - 28 Feb 2013

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