Design, syntheses and biological evaluation of 5-fluoroindolin-2-one derivatives with urea linkage

Baohua Zou, Zheng Fang, Zhao Yang, Kai Guo

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Nine 5-fluoroindolin-2-one derivatives with urea linkage were designed and synthesized. The obtained structures were identified by 1H NMR, MS and elemental analysis. In vitro evaluation of antitumor bioactivity was performed by MTT method. Most of synthesized compounds showed antitumor activities, especially, compounds 6e and 6f, which were better than or equal to the antitumor activity of positive control.

Original languageEnglish
Title of host publicationAdvances in Chemical, Material and Metallurgical Engineering
Pages926-929
Number of pages4
Edition1
DOIs
StatePublished - 2013
Event2012 2nd International Conference on Chemical, Material and Metallurgical Engineering, ICCMME 2012 - Kunming, China
Duration: 15 Dec 201216 Dec 2012

Publication series

NameAdvanced Materials Research
Number1
Volume634-638
ISSN (Print)1022-6680

Conference

Conference2012 2nd International Conference on Chemical, Material and Metallurgical Engineering, ICCMME 2012
Country/TerritoryChina
CityKunming
Period15/12/1216/12/12

Keywords

  • 5-fluoroindolin-2-one
  • Activity
  • Antitumor
  • Synthesis

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