Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

Bin Pan; Ren Zheng Huang; Shi Qing Han; Di Qu; Ming Li Zhu; Ping Wei; Han Jie Ying

doi:10.1016/j.bmcl.2010.03.013

Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

Bin Pan, Ren Zheng Huang, Shi Qing Han, Di Qu, Ming Li Zhu, Ping Wei, Han Jie Ying

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.

Original language	English
Pages (from-to)	2461-2464
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2010.03.013
State	Published - 15 Apr 2010

Keywords

Antibiofilm activity
Thiazolidine

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10.1016/j.bmcl.2010.03.013

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title = "Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones",

abstract = "A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.",

keywords = "Antibiofilm activity, Thiazolidine",

author = "Bin Pan and Huang, {Ren Zheng} and Han, {Shi Qing} and Di Qu and Zhu, {Ming Li} and Ping Wei and Ying, {Han Jie}",

year = "2010",

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doi = "10.1016/j.bmcl.2010.03.013",

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T1 - Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

AU - Pan, Bin

AU - Huang, Ren Zheng

AU - Han, Shi Qing

AU - Qu, Di

AU - Zhu, Ming Li

AU - Wei, Ping

AU - Ying, Han Jie

PY - 2010/4/15

Y1 - 2010/4/15

N2 - A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.

AB - A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.

KW - Antibiofilm activity

KW - Thiazolidine

UR - http://www.scopus.com/inward/record.url?scp=77950299185&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2010.03.013

DO - 10.1016/j.bmcl.2010.03.013

M3 - 文章

C2 - 20346668

AN - SCOPUS:77950299185

SN - 0960-894X

VL - 20

SP - 2461

EP - 2464

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

Abstract

Keywords

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