Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

Bin Pan; Ren Zheng Huang; Shi Qing Han; Di Qu; Ming Li Zhu; Ping Wei; Han Jie Ying

doi:10.1016/j.bmcl.2010.03.013

Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

Bin Pan, Ren Zheng Huang, Shi Qing Han, Di Qu, Ming Li Zhu, Ping Wei, Han Jie Ying

生物与制药工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

53 引用（Scopus）

摘要

A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.

源语言	英语
页（从-至）	2461-2464
页数	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	20
期	8
DOI	https://doi.org/10.1016/j.bmcl.2010.03.013
出版状态	已出版 - 15 4月 2010

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title = "Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones",

abstract = "A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.",

keywords = "Antibiofilm activity, Thiazolidine",

author = "Bin Pan and Huang, {Ren Zheng} and Han, {Shi Qing} and Di Qu and Zhu, {Ming Li} and Ping Wei and Ying, {Han Jie}",

year = "2010",

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doi = "10.1016/j.bmcl.2010.03.013",

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T1 - Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

AU - Pan, Bin

AU - Huang, Ren Zheng

AU - Han, Shi Qing

AU - Qu, Di

AU - Zhu, Ming Li

AU - Wei, Ping

AU - Ying, Han Jie

PY - 2010/4/15

Y1 - 2010/4/15

N2 - A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.

AB - A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.

KW - Antibiofilm activity

KW - Thiazolidine

UR - http://www.scopus.com/inward/record.url?scp=77950299185&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2010.03.013

DO - 10.1016/j.bmcl.2010.03.013

M3 - 文章

C2 - 20346668

AN - SCOPUS:77950299185

SN - 0960-894X

VL - 20

SP - 2461

EP - 2464

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

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