Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes

Ziren Mao; Yiliang Zhou; Jingming Zhang; Chengkou Liu; Chang Sheng Wang; Xiaobing Yang; Hong Qin; Zheng Fang; Kai Guo

doi:10.1039/d3nj05081e

Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes

Ziren Mao, Yiliang Zhou, Jingming Zhang, Chengkou Liu, Chang Sheng Wang, Xiaobing Yang, Hong Qin, Zheng Fang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An efficient strategy to construct α-alkynyl ketones through electrochemical difunctionalization of alkenes was developed. This method is oxidant-free, metal-free, high-efficiency and eco-friendly, and offers rapid constructions of 1,2-alkynyl migration products through the radical process of 3-exo-dig cyclization. Moreover, the reaction could undergo a successful transformation under continuous-flow conditions.

Original language	English
Pages (from-to)	1735-1740
Number of pages	6
Journal	New Journal of Chemistry
Volume	48
Issue number	4
DOIs	https://doi.org/10.1039/d3nj05081e
State	Published - 2 Dec 2023

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title = "Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes",

abstract = "An efficient strategy to construct α-alkynyl ketones through electrochemical difunctionalization of alkenes was developed. This method is oxidant-free, metal-free, high-efficiency and eco-friendly, and offers rapid constructions of 1,2-alkynyl migration products through the radical process of 3-exo-dig cyclization. Moreover, the reaction could undergo a successful transformation under continuous-flow conditions.",

author = "Ziren Mao and Yiliang Zhou and Jingming Zhang and Chengkou Liu and Wang, {Chang Sheng} and Xiaobing Yang and Hong Qin and Zheng Fang and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2024 The Royal Society of Chemistry.",

year = "2023",

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T1 - Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes

AU - Mao, Ziren

AU - Zhou, Yiliang

AU - Zhang, Jingming

AU - Liu, Chengkou

AU - Wang, Chang Sheng

AU - Yang, Xiaobing

AU - Qin, Hong

AU - Fang, Zheng

AU - Guo, Kai

PY - 2023/12/2

Y1 - 2023/12/2

N2 - An efficient strategy to construct α-alkynyl ketones through electrochemical difunctionalization of alkenes was developed. This method is oxidant-free, metal-free, high-efficiency and eco-friendly, and offers rapid constructions of 1,2-alkynyl migration products through the radical process of 3-exo-dig cyclization. Moreover, the reaction could undergo a successful transformation under continuous-flow conditions.

AB - An efficient strategy to construct α-alkynyl ketones through electrochemical difunctionalization of alkenes was developed. This method is oxidant-free, metal-free, high-efficiency and eco-friendly, and offers rapid constructions of 1,2-alkynyl migration products through the radical process of 3-exo-dig cyclization. Moreover, the reaction could undergo a successful transformation under continuous-flow conditions.

UR - http://www.scopus.com/inward/record.url?scp=85181830824&partnerID=8YFLogxK

U2 - 10.1039/d3nj05081e

DO - 10.1039/d3nj05081e

M3 - 文章

AN - SCOPUS:85181830824

SN - 1144-0546

VL - 48

SP - 1735

EP - 1740

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 4

ER -

Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes

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