Direct construction of imino-pyrrolidine-thione scaffold via isocyanide-based multicomponent reaction

Xu Zhu; Xiao Ping Xu; Chang Sun; Hai Ying Wang; Kai Zhao; Shun Jun Ji

doi:10.1021/cc100014g

Direct construction of imino-pyrrolidine-thione scaffold via isocyanide-based multicomponent reaction

Xu Zhu, Xiao Ping Xu, Chang Sun, Hai Ying Wang, Kai Zhao, Shun Jun Ji

Soochow University

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.

Original language	English
Pages (from-to)	822-828
Number of pages	7
Journal	Journal of Combinatorial Chemistry
Volume	12
Issue number	6
DOIs	https://doi.org/10.1021/cc100014g
State	Published - 8 Nov 2010
Externally published	Yes

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10.1021/cc100014g

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abstract = "A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.",

author = "Xu Zhu and Xu, {Xiao Ping} and Chang Sun and Wang, {Hai Ying} and Kai Zhao and Ji, {Shun Jun}",

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AU - Zhu, Xu

AU - Xu, Xiao Ping

AU - Sun, Chang

AU - Wang, Hai Ying

AU - Zhao, Kai

AU - Ji, Shun Jun

PY - 2010/11/8

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N2 - A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.

AB - A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.

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M3 - 文章

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AN - SCOPUS:78149319118

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JO - Journal of Combinatorial Chemistry

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Direct construction of imino-pyrrolidine-thione scaffold via isocyanide-based multicomponent reaction

Abstract

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