Direct construction of imino-pyrrolidine-thione scaffold via isocyanide-based multicomponent reaction

Xu Zhu; Xiao Ping Xu; Chang Sun; Hai Ying Wang; Kai Zhao; Shun Jun Ji

doi:10.1021/cc100014g

Direct construction of imino-pyrrolidine-thione scaffold via isocyanide-based multicomponent reaction

Xu Zhu, Xiao Ping Xu, Chang Sun, Hai Ying Wang, Kai Zhao, Shun Jun Ji

Soochow University

科研成果: 期刊稿件 › 文章 › 同行评审

28 引用（Scopus）

摘要

A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.

源语言	英语
页（从-至）	822-828
页数	7
期刊	Journal of Combinatorial Chemistry
卷	12
期	6
DOI	https://doi.org/10.1021/cc100014g
出版状态	已出版 - 8 11月 2010
已对外发布	是

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abstract = "A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.",

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AU - Zhao, Kai

AU - Ji, Shun Jun

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AB - A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.

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Direct construction of imino-pyrrolidine-thione scaffold via isocyanide-based multicomponent reaction

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