Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

Chao Feng; Teck Peng Loh

doi:10.1002/anie.201307245

Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

Chao Feng, Teck Peng Loh

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF₃-functionalized acrylamide derivatives.

Original language	English
Pages (from-to)	12414-12417
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	47
DOIs	https://doi.org/10.1002/anie.201307245
State	Published - 18 Nov 2013
Externally published	Yes

Keywords

C-H activation
alkenes
copper
cross-coupling
trifluoromethylation

Access to Document

10.1002/anie.201307245

Cite this

@article{69902a1e139040cf8f530dff021d0a7f,

title = "Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes",

abstract = "Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.",

keywords = "C-H activation, alkenes, copper, cross-coupling, trifluoromethylation",

author = "Chao Feng and Loh, {Teck Peng}",

year = "2013",

month = nov,

day = "18",

doi = "10.1002/anie.201307245",

language = "英语",

volume = "52",

pages = "12414--12417",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "47",

}

TY - JOUR

T1 - Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

AU - Feng, Chao

AU - Loh, Teck Peng

PY - 2013/11/18

Y1 - 2013/11/18

N2 - Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.

AB - Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.

KW - C-H activation

KW - alkenes

KW - copper

KW - cross-coupling

KW - trifluoromethylation

UR - http://www.scopus.com/inward/record.url?scp=84887516902&partnerID=8YFLogxK

U2 - 10.1002/anie.201307245

DO - 10.1002/anie.201307245

M3 - 文章

C2 - 24123499

AN - SCOPUS:84887516902

SN - 1433-7851

VL - 52

SP - 12414

EP - 12417

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 47

ER -

Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this