Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

Chao Feng; Teck Peng Loh

doi:10.1002/anie.201307245

Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

Chao Feng, Teck Peng Loh

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124 引用（Scopus）

摘要

Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF₃-functionalized acrylamide derivatives.

源语言	英语
页（从-至）	12414-12417
页数	4
期刊	Angewandte Chemie - International Edition
卷	52
期	47
DOI	https://doi.org/10.1002/anie.201307245
出版状态	已出版 - 18 11月 2013
已对外发布	是

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abstract = "Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.",

keywords = "C-H activation, alkenes, copper, cross-coupling, trifluoromethylation",

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AU - Loh, Teck Peng

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N2 - Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.

AB - Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.

KW - C-H activation

KW - alkenes

KW - copper

KW - cross-coupling

KW - trifluoromethylation

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Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

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