Electrosynthesis of Spiro-indolenines via Dearomative Arylation of Indoles in Batch and Continuous Flow

Wei Zhao; Yi Lu; Yaqi Qiao; Xing Yin; Chengkou Liu; Zheng Fang; Jianliang Zhu; Kai Guo

doi:10.1021/acs.orglett.3c03149

Electrosynthesis of Spiro-indolenines via Dearomative Arylation of Indoles in Batch and Continuous Flow

Wei Zhao, Yi Lu, Yaqi Qiao, Xing Yin, Chengkou Liu, Zheng Fang, Jianliang Zhu, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

An electrosynthesis of spiro-indolenines in batch and continuous flow was achieved through dearomative arylation of indoles with good functional group compatibility. User-friendly undivided cells were used under catalyst- and oxidant-free conditions. Moreover, the use of a flow electrolysis cell gave high daily productivity and excellent scale-up potential under less supporting electrolyte and higher substrate concentration conditions.

Original language	English
Pages (from-to)	7451-7456
Number of pages	6
Journal	Organic Letters
Volume	25
Issue number	40
DOIs	https://doi.org/10.1021/acs.orglett.3c03149
State	Published - 13 Oct 2023

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abstract = "An electrosynthesis of spiro-indolenines in batch and continuous flow was achieved through dearomative arylation of indoles with good functional group compatibility. User-friendly undivided cells were used under catalyst- and oxidant-free conditions. Moreover, the use of a flow electrolysis cell gave high daily productivity and excellent scale-up potential under less supporting electrolyte and higher substrate concentration conditions.",

author = "Wei Zhao and Yi Lu and Yaqi Qiao and Xing Yin and Chengkou Liu and Zheng Fang and Jianliang Zhu and Kai Guo",

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T1 - Electrosynthesis of Spiro-indolenines via Dearomative Arylation of Indoles in Batch and Continuous Flow

AU - Zhao, Wei

AU - Lu, Yi

AU - Qiao, Yaqi

AU - Yin, Xing

AU - Liu, Chengkou

AU - Fang, Zheng

AU - Zhu, Jianliang

AU - Guo, Kai

PY - 2023/10/13

Y1 - 2023/10/13

N2 - An electrosynthesis of spiro-indolenines in batch and continuous flow was achieved through dearomative arylation of indoles with good functional group compatibility. User-friendly undivided cells were used under catalyst- and oxidant-free conditions. Moreover, the use of a flow electrolysis cell gave high daily productivity and excellent scale-up potential under less supporting electrolyte and higher substrate concentration conditions.

AB - An electrosynthesis of spiro-indolenines in batch and continuous flow was achieved through dearomative arylation of indoles with good functional group compatibility. User-friendly undivided cells were used under catalyst- and oxidant-free conditions. Moreover, the use of a flow electrolysis cell gave high daily productivity and excellent scale-up potential under less supporting electrolyte and higher substrate concentration conditions.

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U2 - 10.1021/acs.orglett.3c03149

DO - 10.1021/acs.orglett.3c03149

M3 - 文章

C2 - 37791903

AN - SCOPUS:85174751056

SN - 1523-7060

VL - 25

SP - 7451

EP - 7456

JO - Organic Letters

JF - Organic Letters

IS - 40

ER -

Electrosynthesis of Spiro-indolenines via Dearomative Arylation of Indoles in Batch and Continuous Flow

Abstract

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