Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

Kai Qiao; Xin Yuan; Li Wan; Ming Wei Zheng; Dong Zhang; Bing Bing Fan; Zhe Chen Di; Zheng Fang; Kai Guo

doi:10.1039/c7gc02682j

Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

Kai Qiao, Xin Yuan, Li Wan, Ming Wei Zheng, Dong Zhang, Bing Bing Fan, Zhe Chen Di, Zheng Fang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

Original language	English
Pages (from-to)	5789-5793
Number of pages	5
Journal	Green Chemistry
Volume	19
Issue number	24
DOIs	https://doi.org/10.1039/c7gc02682j
State	Published - 2017

Access to Document

10.1039/c7gc02682j

Cite this

@article{5a124c07ab764cb3a3fa72e8d514b528,

title = "Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines",

abstract = "A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.",

author = "Kai Qiao and Xin Yuan and Li Wan and Zheng, {Ming Wei} and Dong Zhang and Fan, {Bing Bing} and Di, {Zhe Chen} and Zheng Fang and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7gc02682j",

language = "英语",

volume = "19",

pages = "5789--5793",

journal = "Green Chemistry",

issn = "1463-9262",

publisher = "Royal Society of Chemistry",

number = "24",

}

TY - JOUR

T1 - Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

AU - Qiao, Kai

AU - Yuan, Xin

AU - Wan, Li

AU - Zheng, Ming Wei

AU - Zhang, Dong

AU - Fan, Bing Bing

AU - Di, Zhe Chen

AU - Fang, Zheng

AU - Guo, Kai

PY - 2017

Y1 - 2017

N2 - A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

AB - A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

UR - http://www.scopus.com/inward/record.url?scp=85038440801&partnerID=8YFLogxK

U2 - 10.1039/c7gc02682j

DO - 10.1039/c7gc02682j

M3 - 文章

AN - SCOPUS:85038440801

SN - 1463-9262

VL - 19

SP - 5789

EP - 5793

JO - Green Chemistry

JF - Green Chemistry

IS - 24

ER -

Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

Abstract

Access to Document

Other files and links

Fingerprint

Cite this